The corrosion of the medicinal glass bottle by the alkali is much stronger than that of the acid, because the medicinal glass bottle contains sodium silicate, silicic acid, etc., which is not easy to react with the alkali. The mouth hair is because the surface area is larger than the smooth glass, so that the alkali is contacted. The liquid area is also large, so chemical reactions are likely to occur.

Silica and alkali solution such as sodium hydroxide or calcium hydroxide can react at room temperature: SiO2+2NaOH=Na2SiO3+H2O

It is for this reason that concentrated sodium hydroxide solution is stored for a long time in a glass bottle with a glass stopper. The glass bottle is usually polished, SiO2 is exposed, and it is more reactive with sodium hydroxide to form a sticky Na2SiO3, which makes the stopper and the glass bottle stick and is not easy to open. Even with glass bottles with rubber stoppers, it is not easy to store concentrated sodium hydroxide solution for a long time. Concentrated sodium hydroxide solution is usually stored in plastic bottles. The glass bottle wall has a smooth and alkali-resistant glaze layer, and the glass bottle with the rubber stopper can store the sodium hydroxide solution for a short time.